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This review focuses on the current status of understanding the multiple functions of Rho-ROCK signaling pathways and various modes of regulation of Rho-ROCK ...
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Regarding the specificity, cAMP-dependent protein kinase (PKA) and protein kinase C are also inhibited by fasudil with Ki values of 1.0 μM and 9.3 μM, ...
Classification of small molecule protein kinase inhibitorsa. Inhibitor type, Properties. I, Binds in and around the ATP-binding pocket of an active enzyme.
In enzymology, the term serine/threonine protein kinase describes a class of enzymes in the family of transferases, that transfer phosphates to the oxygen atom ...
A unique collection of 1252 serine/threonine kinase inhibitors for high throughput screening (HTS) and high content screening (HCS). • The library contains ...
Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral infection, through the activation of the type I IFN, ...
Title: Protein kinase A in complex with Rho-kinase inhibitors Y-27632, Fasudil, and H-1152P: structural basis of selectivity. Authors: Breitenlechner, C. / ...
Purpose.: To investigate the effect of a specific inhibitor of Rho-associated protein kinase, Y-27632, on monkey Schlemm's canal endothelial (SCE) cells.
Protein Structure—The structure of Pim-1 has a global fold typical of protein serine/threonine kinases, consisting of two domains linked by a hinge region ...
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The CC1 pan-Kinase Inhibitor is a chemically synthesized compound that broadly binds to kinases, as determined using the NanoBRET® Target Engagement (TE) ...